The recent tragic deaths of fashion designer Kate Spade and celebrity chef Anthony Bourdain have ignited concern about the dramatic rise in suicides in the past two decades. According to a report released earlier this month by the Centers for Disease Control and Prevention, suicide rates increased 28 percent since 1999.

Here are a few articles we’ve come across that discuss depression’s role in suicide and a number of warning signs that can help determine if a person is at risk.

According to a story in, warning signs of suicide can vary from person to person. Some may talk outwardly about their thoughts of suicide, while others my keep their intentions secret. “Look for changes in pattern,” says Christine Moutier, MD, chief medical officer at the American Foundation for Suicide Prevention:

On radio station WBUR’s Here & Now program, Dr. Drew Ramsey, assistant clinical professor of psychiatry at Columbia University, says that suicide risk factors are having a prior suicide attempt, having a mood disorder such as depression, and having a substance abuse or alcohol abuse disorder:

In Psychology Today, psychologist Pam Garcy points out that the recent celebrity suicides can serve as a wake-up call for men in particular to stop buying into traditional gender norms and hiding their emotional side, being told when they were boys to “shake it off” and “man up.” Almost two-thirds of worldwide suicides are committed by men, who are less likely to get help:

If someone you know may be considering suicide, contact the National Suicide Prevention Lifeline at 1-800-273-8255 (En Español: 1-888-628-9454) or the Crisis Text Line by texting 741741.